K-PAX Osteo Builder

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K-PAX Osteo Builder

$74.95

State-of-the-Art Bone Strengthening Packets containing Calcium, Magnesium, Vitamin D, Ipriflavone, and Vitamin K

Quantity:

60 packets

K-PAX Osteo Builder is a highly effective bone building supplement that is formulated for maximum results and convenience. Packaged in easy-to-use packets, K-PAX Osteo Builder addresses both the prevention of bone loss and the promotion of its growth.

K-PAX Osteo Builder contains key bone nutrients that are often under-represented in other products. These include: calcium hydroxyapatite, magnesium, vitamin D, ipriflavone, and vitamin K

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Ingredients

References

Calcium is the mineral that makes up the majority of bone tissue. Research has shown that calcium supplementation has a positive effect on bone density.¹ In general, research studies have made it clear that calcium replacement alone is not optimal for preventing osteoporosis. For example, in a two-year, double-blinded, placebo-controlled trial of healthy postmenopausal women, the combination of calcium, vitamin D, and vitamin K resulted in better improvements in bone density than were seen in women given only calcium with D.² Calcium should always be used in conjunction with the other nutrients that are required for improving bone health, rather than as a single supplement, as is the case in many other bone-building supplements. K-PAX Osteo Builder provides multiple sources of calcium to maximize its absorption from the GI tract. K-PAX Osteo Builder contains 1000 mg of easily absorbable calcium.

Magnesium is a mineral that supports both the metabolism of calcium and the hormones that regulate its use. Magnesium is the fourth most abundant mineral in the body, with approximately 50% of total body magnesium being found in bone. Increased magnesium intake has been associated with increased bone density in elderly men and women³, premenopausal women⁴, and postmenopausal women⁵. Human studies on magnesium supplementation have shown improvement in bone mineral density^6,7, along with other studies indicating an increased risk of post-menopausal osteoporosis in those with low levels of magnesium.⁸

Vitamin D is known to be responsible for day-to-day maintenance of calcium and mineral homeostasis. Furthermore, vitamin D supplementation is proven to support healthy bone density and a decreased incidence of falling in the elderly. Several studies have shown that supplementing with 700 to 800 IU per day of vitamin D results in significant reductions in fractures.^9,10,11 Experts in the field point to an unrecognized epidemic of vitamin D deficiency among older Americans which may be contributing substantially to the development of osteoporosis and the fractures that result from it, as well as to the development of many other chronic diseases.¹² K-PAX Osteo Builder provides 1000 IU of vitamin D3.

Ipriflavone is a plant estrogen-like compound that has been studied in both animal and human trials. Research has shown that ipriflavone increases the absorption of calcium.¹³ Ipriflavone is believed to slow the rate of bone loss while also increasing the rate of bone formation.¹⁴ In two double-blind, placebo-controlled studies, women with osteoporosis given 600 mg per day of ipriflavone combined with 1,000 mg of calcium had a significant increase in bone mineral density and a significant reduction in vertebral fractures, along with significant improvements in bone pain and mobility.¹⁵ Several other studies have shown that supplementing with ipriflavone (generally in doses of 200 mg, three times daily) can prevent bone loss in postmenopausal women.^16,17,18 K-PAX Osteo Builder provides 600 mg of ipriflavone.

Vitamin K is required for the synthesis of osteocalcin, a bone protein which helps provide structure to bone tissue. Without it, our bones would be fragile and more susceptible to breaking. Vitamin K deficiency is common in people diagnosed with osteoporosis.¹⁹ In a very large study of 72,327 women, low intake of vitamin K was shown to be associated with a significantly increased of hip fracture risk.²⁰ In another study, low dietary vitamin K intake was clearly associated with low bone density in women.²¹ In one large study of postmenopausal women that compared the results in those receiving placebo to those given supplementation with either a combination of the nutrients (calcium, magnesium, zinc, and vitamin D) or those same nutrients with the addition of vitamin K, there was significantly less bone loss in the women given the nutrient combination that included vitamin K.²² In a two-year, double-blinded, placebo-controlled trial of healthy postmenopausal women, the combination of calcium, vitamin D, and vitamin K resulted in better improvements to bone health than were seen in women given only calcium and vitamin D.²³ K-PAX Osteo Builder provides 1000 mcg of this important vitamin that is a key for building strong bones.

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Suggested Use

Ingredients

References

1. Calcium supplementation on bone loss in postmenopausal women. Cochrane Database Syst Rev. 2004;1:CD004526. Shea B, Wells G, Cranney A, et al.

2. Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. J Bone Miner Res. 2007;22(4):509-19. Bolton-Smith C, McMurdo ME, Paterson CR, et al.

3. Potassium, magnesium and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 1999;69:727-36. Tucker KL, Hannan MT, Chen H, et al.

4. Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr. 1997;65:1831–9. New SA, Bolton-Smith C, Grubb DA, Reid DM.

5. Dietary intake and bone mineral density. Bone Miner. 1988;4:265–77. Angus RM, Sambrook PN, Pocock NA, Eisman JA.

6. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999. Institute of Medicine. Food and Nutrition Board.

7. Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnes Res. 1993;6:155–63. Stendig-Lindberg G, Tepper R, Leichter I.

8. Calcium, phosphorus, and magnesium intakes correlate with bone mineral content in postmenopausal women. Gynecol Endocrinol. 1994;8:55–8. Tranquilli AL, Lucino E, Garzetti GG, Romanini C.

9. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997;337:670-676. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE.

10. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med. 1992;327:1637-1642. Chapuy MC, Arlot ME, Duboeuf F, et al.

11. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ. 2003;326:469. Trivedi DP, Doll R, Khaw KT.

12. Vitamin D and calcium deficits predispose for multiple chronic diseases. European J Clin Invest. 2005;35:290-304. Peterlik M and Cross HS.

13. Ipriflavone, a synthetic phytoestrogen, enhances intestinal calcium transport in vitro. Calcif Tissue Int. 2000;67(3):225-229. Arjmandi BH, Khalil DA, Hollis BW.

14. In vitro and in vivo effects of ipriflavone on bone formation and bone biomechanics. Calcif Tissue Int. 1997;61 Suppl 1:S12-14. Civitelli R.

15. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int. 1997;61 Suppl 1:S23-27. Agnusdei D, Bufalino L.

16. Bone density changes in postmenopausal women with the administration of ipriflavone alone or in association with low-dose ERT. Gynecol Endocrinol. 1997;11:289-293. de Aloysio D, Gambacciani M, Altieri P, et al.

17. Ipriflavone prevents radial bone loss in postmenopausal women with low bone mass over 2 years. Osteoporos Int. 1997;7(2):119-25. Adami S, Bufalino L, Cervetti R, et al.

18. Inhibitory effect of ipriflavone on vertebral bone mass loss in postmenopausal women with low bone mass. Osteoporos Int. 1996;6(1):93. Mazzuoli GF.

19. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Clin Endocrinol Metab. 1985;60:1268-1269. Hart JP, Shearer MJ, Klenerman L, et al.

20. Vitamin K intake and hip fractures in women: a prospective study. Am J Clin Nutr. 1999;69(1):74-79. Feskanich D, Weber P, Willett WC, et al.

21. Vitamin K Intake and bone mineral density in women and men. Am J Clin Nutr. 2003;77:512-516. Booth SL, Broe KE, Gagnon DR, et al.

22. Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcif Tissue Int. 2003;73(1):21-26. Braam LA, Knapen MH, Geusens P, et al.

23. Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. J Bone Miner Res. 2007;22(4):509-19. Bolton-Smith C, McMurdo ME, Paterson CR, et al.

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